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The Dynamic Bacterial Genome: Advances in Molecular and Cellular Microbiology, cartea 8

Editat de Peter Mullany
en Limba Engleză Paperback – 4 feb 2010
This book provides an in-depth analysis of the mechanisms and biological consequences of genome rearrangements in bacteria. Genome rearrangements are a result of the actions of discrete genetic elements such as conjugative transposons, plasmids, phage, and non-conjugative transposons. Bacteria also contain systems to mediate genetic rearrangements such as the general recombination pathway and specialized endogenous recombination mechanisms. The biological effects of these rearrangements are far-reaching and impact on bacterial virulence, antibiotic resistance and the ability of bacteria to avoid the attentions of the host immune system (e.g. antigenic variation). These rearrangements also provide the raw material on which natural selection can act. Each chapter examines the mechanisms involved in genome rearrangements and the direct biological consequences of these events. This book is written by leading research workers and is an invaluable resource for graduate students and researchers in this field.
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Specificații

ISBN-13: 9780521129619
ISBN-10: 0521129613
Pagini: 444
Dimensiuni: 152 x 229 x 25 mm
Greutate: 0.65 kg
Editura: Cambridge University Press
Colecția Cambridge University Press
Seria Advances in Molecular and Cellular Microbiology

Locul publicării:Cambridge, United Kingdom

Cuprins

Part I. Basic Mechanisms of Genome Rearrangement in Bacteria: 1. Mechanisms of homologous recombination in bacteria Marie-Agnès Petit; 2. Introduction to site-specific recombination Makkuni Jayaram and Ian Grainge; 3. Site-specific recombination by the serine recombinases Sally J. Rowland and W. Marshall Stark; 4. Mobile introns and retroelements in bacteria Steve Zimmerly; Part II. Horizontal Gene Transfer and Genome Plasticity: 5. The F-Plasmid, a paradigm for bacterial conjugation Michael J. Gubbins, William R. Will and Laura S. Frost; 6. Molecular aspects of movement of conjugative transposons Adam P. Roberts and Peter Mullany; 7. Competence for genetic transformation Irena Draskovic and David Dubnau; Part III. Biological Consequences of the Mobile Genome: 8. Phase variation and antigenic variation Richard Villemur and Eric Déziel; 9. Pathogenicity islands Bianca Hochhut and Jörg Hacker; 10. Biological consequences for bacteria of homologous recombination Diarmaid Hughes and Tobias Norström; 11. Horizontal gene transfer and bacterial genomic legacies James R. Brown.

Recenzii

Review of the hardback: 'The book is well structured, thorough and thoughtful, and a rich source of information about the amazing dynamics of bacterial genomes.' Microbiology Today

Descriere

This book is concerned with the mechanisms underlying recombination in bacterial DNA.