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Process Systems Engineering for Pharmaceutical Manufacturing: Computer Aided Chemical Engineering, cartea 41

Editat de Ravendra Singh, Zhihong Yuan
en Limba Engleză Hardback – 20 mar 2018
Process Systems Engineering for Pharmaceutical Manufacturing: From Product Design to Enterprise-Wide Decisions, Volume 41, covers the following process systems engineering methods and tools for the modernization of the pharmaceutical industry: computer-aided pharmaceutical product design and pharmaceutical production processes design/synthesis; modeling and simulation of the pharmaceutical processing unit operation, integrated flowsheets and applications for design, analysis, risk assessment, sensitivity analysis, optimization, design space identification and control system design; optimal operation, control and monitoring of pharmaceutical production processes; enterprise-wide optimization and supply chain management for pharmaceutical manufacturing processes.
Currently, pharmaceutical companies are going through a paradigm shift, from traditional manufacturing mode to modernized mode, built on cutting edge technology and computer-aided methods and tools. Such shifts can benefit tremendously from the application of methods and tools of process systems engineering.


  • Introduces Process System Engineering (PSE) methods and tools for discovering, developing and deploying greener, safer, cost-effective and efficient pharmaceutical production processes
  • Includes a wide spectrum of case studies where different PSE tools and methods are used to improve various pharmaceutical production processes with distinct final products
  • Examines the future benefits and challenges for applying PSE methods and tools to pharmaceutical manufacturing
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Specificații

ISBN-13: 9780444639639
ISBN-10: 0444639632
Pagini: 698
Dimensiuni: 191 x 234 x 41 mm
Greutate: 1.41 kg
Editura: ELSEVIER SCIENCE
Seria Computer Aided Chemical Engineering


Public țintă

Reference for graduates, post graduates and researchers in academia and (pharma) industry. Chemists/ Chemical engineers in pharmaceutical companies. It could be used for novel courses on pharmaceutical systems engineering and by regulators (eg FDA) to familiarize themselves with the current PSE methods and tools.

Cuprins

1. New Product Discovery and Development for Pharmaceutical Industry Catherine Azzaro-Pantel 2. The development of a pharmaceutical oral solid dosage forms Rahamatullah Shaikh, Denise Croker, Donal O'Brien and Gavin Walker 3. Innovative Process Development and Production Concepts for Small-molecule API Manufacturing John Woodley 4. Plantwide Technoeconomic Analysis and Separation Solvent Selection for Continuous Pharmaceutical Manufacturing: Ibuprofen, Artemisinin and Diphenhydramine Dimitrios Gerogiorgis, Samir Diab and Hikaru Jolliffe 5. Flowsheet Modeling of a Continuous Direct Compression Process Seongkyu Yoon 6. Plant-wide Dynamic Model for the Integrated Continuous Pharmaceutical Process: Design of the Recycle Brahim Benyahia 7. Advanced Multi-phase Hybrid Model Development of Fluidized Bed Wet Granulation Processes Rohit Ramachandran, Ashutosh Tamrakar and Dheeraj R. Devarampally 8. Global sensitivity, feasibility and flexibility analysis of continuous pharmaceutical manufacturing processes Marianthi Ierapetritou and Zilong Wang 9. Crystallization process monitoring and control using process analytical technology Levente Simon, Elena Simone and Kaoutar Abbou Oucherif 10. BioProcess Performance Monitoring using Multi-way Interval Partial Least Square Julian Morris, Jie Zhang and Shallon Stubbs 11. Process Dynamics, and control of API manufacturing and purification processe Maitraye Sen, Ravendra Singh and Rohit Ramachandran 12. PAT for pharmaceutical manufacturing process involving solid dosages forms Andrés David Román-Ospino, Carlos Alberto Ortega-Zuniga, Vanessa Cardenas and Ravendra Singh 13. Model-based control system design and evaluation for continuous tablet manufacturing processes (via direct compaction, via roller compaction, via wet granulation) Ravendra Singh 14. Fast Stochastic Model Predictive Control of End-to-end Continuous Pharmaceutical Manufacturing Richard D. Braatz, Ali Mesbah, Joel A. Paulson, Stefan Streif and Rolf Findeisen 15. Advanced Control for the Continuous Dropwise Additive Manufacturing of Pharmaceutical Products Zoltan Nagy, Gintaras Reklatis and Elcin Icten 16. Control System Implementation and Plant-Wide Control of Continuous Pharmaceutical Manufacturing Pilot Plant (End-To-End Manufacturing Process) Richard Lakerveld 17. Automation of continuous pharmaceutical manufacturing process Ravendra Singh 18. Implementation of control system into continuous pharmaceutical manufacturing pilot-plant (powder to tablet) Ravendra Singh 19. Monitoring and control of a continuous tumble mixer Carlos Velazquez Figueroa, Leonel Quiñones and Miguel A. Florian Algarin 20. Flexible Continuous Manufacturing -- Based on S88 Batch Standards and Object Oriented Design Paul Brodbeck 21. Planning Pharmaceutical Clinical Trials under Outcome Uncertainty Selen Cremaschi and Brianna Christian 22. Integrated production planning and inventory management in a multinational pharmaceutical supply chain Naresh Susarla and IA Karimi 23. Optimal Production of Biopharmaceutical Manufacturing Lazaros Papageorgiou and Songsong Liu 24. Perspective on PSE in pharmaceutical process development and innovation-views from academia Rafiqul Gani, John Woodley and Emmanouil Papadakis

Recenzii

“Process Systems Engineering for Pharmaceutical Manufacturing” is a diverse collection of reviews and case studies, most of which were published previously. While this book provides an excellent summary of process modelling and computing with a view to the increased importance of robust simulation tools in pharmaceutical process development and manufacturing, more recent journal publications may provide additional or more in-depth information on the current state of specific technologies or algorithms described in the book. It is also evident that much of the key work in these areas has yet to be done. One topic missing from discussion in the book is the advent of quantum computing and the potential quantum computing presents in solving optimisation problems in process systems engineering. I would look forward to seeing an additional volume added to the series as the technology develops" --Johnson Matthey Technology Review