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Neonatal and Pediatric Pharmacology: Therapeutic Principles in Practice

Editat de Sumner J. Yaffe MD, Jacob V. Aranda
en Limba Engleză Hardback – 12 oct 2010
Written by experts at the forefront of current research and clinical practice,Neonatal and Pediatric Pharmacologyprovides evidence-based guidelines for safe, effective, and rational drug therapy in newborns, children, and adolescents. Coverage includes specific recommendations for all major drug classes and diseases, a detailed section on drugs and the newborn, and chapters on specific treatment settings such as the pediatric intensive care unit and emergency room. Also included are chapters on adverse effects and interactions and state-of-the-art discussions on pharmacokinetics, pharmacodynamics, pharmacogenetics, pharmacogenomics, pharmacoproteomics, drug development, and clinical trials in infants and children. Appendices include a neonatal formulary and a pediatric formulary.

The Fourth Edition includes updated information on drug interactions and regulatory issues. New chapters cover nutrient supplements and biotransformation of medications by the human placenta.
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Specificații

ISBN-13: 9780781795388
ISBN-10: 0781795389
Pagini: 1072
Ilustrații: Illustrations
Dimensiuni: 213 x 276 x 42 mm
Greutate: 2.63 kg
Ediția:Fourth
Editura: LWW
Colecția Lww

Recenzii

"This is truly the gold standard of pediatric and neonatal pharmacology. It is much more extensive than the standard pediatric drug formulary handbooks and its size means it is designed to be a reference in the office and not carried in one's lab coat pocket. However, it is a must-have reference for every pediatric ward and specialty unit since drug therapy is so essential and often misunderstood and misused."

Weighted Numerical Score: 98 - 5 Stars!

Doody Enterprises, Inc. book review, February 2011

"Neonatal and Pediatric Pharmacologyis a well-presented, comprehensive resource covering basic pediatric pharmacology and the therapeutic principles that underlie the use of medications in newborns and children. It will be a helpful reference for all practitioners who care for children and invaluable for those who conduct research or teach."

John L. Zeller, MD, PhD, Contributing Editor, Journal of the American Medical Association

Cuprins

I: GENERAL PRINCIPLES"

1: Introduction and Historical Perspectives

2: Clinical Pharmacokinetics in Infants and Children

3: Drug Action and Therapy in the Infant and Child

4: Drug Metabolism and Disposition in Infants and Children

5: Pharmacogenetics, Pharmacogenomics, and Pharmacoproteomics

6: Compliance with Pediatric Medication Regimens

7: Clinical Trials Involving Children: History, Rationale, Regulatory Framework, and Technical Considerations

8: Ethics of Drug Research in Pediatric Populations

9: Therapeutic Drug Monitoring

10: Drug Formulations

II: DRUGS AND THE NEWBORN

11: Developmental Toxicology

12: Biotransformation of Medications by Human Placenta

13: Maternal Drug Intake and the Newborn

14: Principles of Neonatal Pharmacology

15: Perinatal Origins of Adult Defects in Drug Metabolism

16: Renal Function and Excretion of Drugs in the Newborn

17: The Excretion of Drugs and Chemicals in Human Milk

18: Drugs for Hyperbilirubinemia

19: Drugs and Lung Development

20: Pharmacologic Treatment of Neonatal Apnea

21: Drugs and Perinatal Brain Injury

22: Antiretroviral Pharmacology in Pregnant Women and Newborns

III: DRUGS IN SPECIAL POPULATIONS AND SETTINGS

23: Therapeutic Applications in Pediatric Intensive Care

24: Drug Therapy in the Pediatric Emergency Department

25: Drug Therapy in the Adolescent

26: Topical Medications

27: Ophthalmologic Drugs in Infants and Children

IV: SPECIFIC DRUGS

28: Sulfonamides

29: Penicillins, Cephalosporins, and Other Beta-Lactams

30: Aminoglycosides and Glycopeptides

31: Fluoroquinolones

32: Macrolides, Chloramphenicol, and Tetracyclines

33: Anthelminthic Drugs in Children

34: Antituberculosis Drugs

35: Antifungal Agents

36: Antiviral Drugs: Treatment of the Fetus and Newborn

37: Anticonvulsants

38: Psychopharmacology in Children and Adolescents

39: Antihistamine Drugs

40: Antiasthmatics

41: Antipyretics

42: Cardiovascular Drugs

43: Diuretics

44: Clinical Pharmacology of Antineoplastic Drugs

45: Immunosuppressive and Immunomodulatory Drugs

46: Analgesic Agents

47: Local Anesthetics for Infants and Children

48: Nonsteroidal Anti-inflammatory Drugs

49: Antihypertensive Agents

50: Gastrointestinal Drugs

51: Glucocorticoids

52: Insulin and Diabetes Mellitus

53: Thyroid Hormones

54: Growth Hormone

55: Hematologic Agents

56: Nutrient Supplements

57: Childhood Vaccines

V: ADVERSE DRUG EFFECTS AND INTERACTIONS

58: Epidemiology of Adverse Drug Effects

59: Mechanisms of Adverse Drug Reactions

60: Medication Errors

61: Pediatric Poisonings and Antidotes

62: Use of Herbal Products in Children: Risks and Unproven Benefits

63: Neonatal Abstinence Syndromes

64: Drug Interactions in Newborns and Children

VI: APPENDIX

65: Drug Formulary for the Newborn

66: Pediatric Drug Formulary

Descriere

Written by experts at the forefront of current research and clinical practice,Neonatal and Pediatric Pharmacologyprovides evidence-based guidelines for safe, effective, and rational drug therapy in newborns, children, and adolescents. Coverage includes specific recommendations for all major drug classes and diseases, a detailed section on drugs and the newborn, and chapters on specific treatment settings such as the pediatric intensive care unit and emergency room. Also included are chapters on adverse effects and interactions and state-of-the-art discussions on pharmacokinetics, pharmacodynamics, pharmacogenetics, pharmacogenomics, pharmacoproteomics, drug development, and clinical trials in infants and children. Appendices include a neonatal formulary and a pediatric formulary.

The Fourth Edition includes updated information on drug interactions and regulatory issues. New chapters cover nutrient supplements and biotransformation of medications by the human placenta.